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Simply upload your CV to start getting matched with pha - 17 Jul 2018 22:54


Every day we have new job opportunities arising at top 10 pharmaceutical companies across the globe. ProClinical is a speFildenat recruitment company operating exclusively in the life science industry. There was particular growth with some of Pfizer's key products, including Ibrance (60% increase), Eliquis and Xeljanz.

The company received ten FDA approvals and many of its best-selling products have many years of patent protection remaining. The world's largest pharmaceutical company is multinational pharma giant Pfizer, headquartered in Connecticut, USA. The company looks forward to six potential drug submissions in 2018, including Actemra for rheumatoid arthritis and systemic sclerosis, and Tecentriq for various types of cancer.

The company develops innovative drugs and devices in a number of key indications, such as oncology, immunology, infectious diseases and neuroscience. The company saw 4.2% revenue growth within its pharmaceutical sector, which contributes 85.44% of the company's total revenue. Like Novartis, the company saw only modest revenue growth since 2016 but sales were boosted by the continued success of Merck's bestselling drugs: cancer immunotherapy Keytruda, HPV vaccine Gardasil and diabetes pill Januvia.

One of the leading pharmaceutical companies in Switzerland, Novartis comfortably makes the top 10 pharma list for 2018. This is just one of the many promising pipelined drugs in AbbVie's varied portfolio which spans multiple therapy areas, including dermatology, oncology, neurology and gastroenterology. AbbVie has recently announced that upadacitinib, one of their most anticipated drugs in development that will be used to treat moderate to severe atopic dermatitis, has been granted breakthrough therapy designation by the FDA.

Research-driven American biopharma AbbVie has climbed into the top 10 pharmaceutical companies list for the second year running, with an impressive revenue increase of 10.39%. Gilead reported that the best-selling drugs of 2017 were Harvoni, used to treat Hepatitis C, Truvada to treat and prevent HIV infections and Epclusa, another successful Hepatitis C drug. The company enjoyed 7% revenue growth compared with 2016 figures, with sales being boosted by GSK's best-selling HIV drugs Trivicay and Triumeq, the Ellipta inhaler for asthma and COPD and Nucala, another successful asthma treatment.

This change is in part due to the success of various Amgen products, including Repatha (126% increase), BLINCYTO® (52% increase) and Prolia® (20% increase). This is the first time that Amgen has made ProClinical's top 10 pharma list. Description Here is an exciting pharmaceutical job one of the industry's most prestigious organisations.

Description Here is a chance to join one of the most globally known pharmaceutical organisations, who is looking to hire a Quality Assurance Manager based in Zuchwil. Already today, automation and digitalization are transforming the pharmaceutical industry. Through XHQ, you have a single and coherent view of information for all operations in your pharmaceutical production units.

With our SIMATIC IT Preactor production planning and scheduling software products, you can improve the synchronization of your manufacturing processes, giving you greater visibility and control to increase utilization and on-time delivery while reducing inventory levels and waste.,,20307067,00.html - Comments: 0

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Daily dosing of phosphodiesterase 5 inhibitors. One important issue is whether treatment with a different PDE5-I might salvage a patient that has failed to respond to one of the drugs in this class. Shifting patients to another phosphodiesterase 5 inhibitor.

‘High-dose' (overdosing) phosphodiesterase 5 inhibitors therapy. Furthermore, in the large trial 53 , although only hypogonadal patients were enrolled, testosterone supplementation was initiated after a Fildena-alone run-in period, at the end of which testosterone increased up to the normal range 54. Aripiprazole may improve the severity of sexual dysfunction, especially in ‘ease of sexual arousal' and ‘penile erection', by decreasing serum prolactin level because of D2 partial dopaminergic agonism 45,46 ED is common in men with hyperthyroidism and hypothyroidism 47,48 Treatment of the thyroid disorders may restore erectile function.

Prevention and treatment of ED concomitant diseases may not only improve the response to PDE5-Is but also serve to slow the progression of ED as underlying pathophysiological processes known to cause compromised erectile function are attenuated. In one unique randomized, open-label study of 60 patients with ED, one half of the participants were on PDE5-Is alone and the other half combined the drug with regular exercise for 3 months. Modification of lifestyle factors could help to improve erectile dysfunction (ED) as well as to reduce the risks of developing cardiovascular disease 16,17 It was hypothesized that lifestyle interventions improve endothelial function and nitric oxide (NO) bioavailability, and this may result in benefits on erectile function 18 These modifications may include increasing exercise, weight reduction, stopping smoking, and adherence to a Mediterranean diet.

Dosing instructions of PDE5-Is should include the time of onset, duration of efficacy, highest recommended dosage, the number of therapeutic trials, drug-drug interactions that may decrease or enhance the efficacy of the drug, and sufficient clarification of safety issues ( Table 1 ). Most patients who take PDE5-Is report that the drug takes at least 1 h to achieve the maximum effect, although the onset of effectiveness can range from 15 to 60 min 7 However, maximal efficacy of Fildena may show a broad individual range between 30 and 720 min 2 In the event that the first dose is unsuccessful, the patient must be advised to remain persistent and attempt intercourse on at least four occasions after taking the maximum dose of the PDE5-Is before aborting therapy. Re-education on the pharmacokinetic/dynamics of phosphodiesterase 5 inhibitors. It has been shown that 50% of nonresponders unaware of sexual stimulation can be converted to responders when told that the drug does not possess aphrodisiac properties and that appropriate sexual stimulation is needed 6 This should be applied to both PDE5-Is-naive patients and patients reporting oral treatment failure. - Comments: 0

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Fildena is a effective generic alternative for curing Erectile Dysfunction (ED) in men. Through further study and testing this ingredient became the number one treatment for erectile dysfunction in 1998. Fildena 50mg help to fortune healthcare fildena testimonials cut off your popular treatment medication and should help to maintain problems intended for proper peritoneum.

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Fildena is among the generic brand treatments available - 18 May 2018 19:44


The sufferers with erectile dysfunction are generally those males who are incapable of getting an erection even if they desired to. Although there are times which males tend to experience problems in getting an erection, erectile dysfunction is a far more chronic condition caused by several factors.

The common notion for patients with erection dysfunction is that they are all old; actually, younger males can also have erectile dysfunction and not just the older male population. Erection dysfunction is affected by several factors and not just by age. Contributing elements for ED involve lifestyle elements like chronic drug abuse, alcoholism, and serious smoking. These habits donate to the development of more severe cases of ED, specifically in younger men (those aged 40 or significantly less). Psychological factors likewise affect the expansion of the condition in males; individuals who will be depressed, anxious, stressed, and emotionally drained/ill are most likely to develop the dysfunction. Disorders like diabetes, obesity, long-term hypertension, and prostate problems are also some of the factors which may donate to the incidence of erection dysfunction. Injury to the spine, male genitals and the urologic program also cause erection dysfunction in the male population.

What makes Fildena effective?

PDE5 Inhibitors

Fildena is considered a powerful treatment for the ED condition because it contains among the drugs belonging to the PDE5 inhibitor family or perhaps the phosphodiesterase type 5 inhibitors. Drugs owned by that category are:

Sildenafil Citrate



These three are the only known PDE5 inhibitors and so are all capable of creating good results when found in patients with erectile dysfunction. Fildena provides Sildenafil Citrate, which can be the active component of the brand-name treatment Viagra. Due to their similarity when it comes to the active pharmaceutical ingredients (APIs), Fildena, along with the different generic Sildenafil treatment options, are also called “generic Viagra” products.

PDE5 Inhibitor Function

So how does indeed a PDE5 inhibitor like Fildena gets results? The answer lies in the nature of PDE5 inhibitors. You can tell from the drug family’s brand what it can do-PDE5 inhibitors inhibit PDE5, an enzyme found in the penile tissues. PDE5 is responsible for the degradation of cGMP (cyclic guanosine monophosphate), the major person in the erectile response in people. Since PDE5 destroys cGMP before it in fact should, the erectile response will not occur or occurs alternatively briefly in the patients afflicted with erectile dysfunction.

The inhibiting ability of PDE5 inhibitors such as for example Fildena is essential in assisting patients with ED maintain their erectile function by allowing the degrees of cGMP to increase to adequate concentrations which permit the vasodilation and the filling of the penile tissue with blood, therefore leading to an erection. But, this PDE5 inhibitor drugs effect just works in the presence of sexual stimuli, as the cGMP is released only after sexual stimulation.

Who makes Fildena?

The maker of Fildena is Fortune Healthcare, a pharmaceutical company positioned in India. The firm is a young enterprise which was established in 2009 2009 and is focused on the production, advertising, trading, and distribution of pharmaceutical products for tuberculosis, bacterial infections, veterinary items, Ayurvedic remedies, sexual health prescription drugs, and more.

The company currently suits mostly India and Asian countries just like Vietnam and the Philippines (Fortune Healthcare has 40 products approved by the Philippine FDA), in fact it is also known to export some of its products in the United States. Fortune Health care has its ISO 9001:2000 certification for product quality and has yet to get other accreditations for top quality manufacturing and production processes.

How do you take Fildena?

Fildena will come in various dosage strengths (25, 50, and 100 mg) and in addition in special formulations. The medication is intended to be taken only once within 24 hours (irrespective of medication dosage) and on an on-demand basis only (the drug is not a maintenance medication needed to be taken daily). It is best to be taken without food and its effect can previous up to 4 hours.

Fildena side effects

Let's dicuss Fildena side effects-does the medicine have unwanted effects in users? All medicines have side effects and Fildena is normally no exception. Fildena side effects may be observed in patients using the drug for the very first time, and possibly in sufferers who happen to be chronic or long-term users of the drug. The Fildena side effects may be related to its effective pharmaceutical ingredient, Sildenafil Citrate, which though highly potent, has the ability to cause a quantity of unwanted but tolerable side effects in its sufferers. There are common reports of Fildena side effects and some of them include:


Facial redness/facial flushing

Transient blurry vision

Back pain




Other GI upset symptoms


These side effects are the ones commonly reported for Fildena use, but not all users or individuals prescribed with Fildena get to experience such side effects. These side effects ought to be transient and should go away when the drug is usually metabolized or excreted from your body. These unwanted effects should certainly not be persistent; in the event that you think that these unwanted effects are lasting more than they should, after that you should go ahead and consult your physician for medical support. Those mentioned aren't the only possible unwanted effects which users may encounter because of Fildena drug use. In fact, there are other major unwanted effects which may be attributed to the Sildenafil content material of Fildena. They are the major Fildena side effects which patients should be watching out for:

Allergic reaction symptoms (rashes, swollen face and/or throat, itchiness, scaling, urticaria)


Vision loss

Hearing loss



Painful erection long lasting for 4 hours or more

Chest pain or heavy feeling

Heart attack symptoms

Urinary tract infections

Nausea, vomiting


Cold sweats


Shortness of breath

Edema found in the hands and/or feet

Lightheadedness or fainting

Although we have listed the next Fildena side effects, these unwanted effects are not all of the possible small and serious side effects for Fildena use. There may also be other side effects patients may experience which are not indicated in the set of side effects. Patients may be asymptomatic and could take the medication well, and there can also be moments that a patient gets to experience more than one side-effect due to the medication. People may have numerous responses to Fildena, so it is important that individuals get tested and assessed effectively before taking Fildena or other Sildenafil-containing medication for erection dysfunction to prevent the incidence of these side effects.

Things you should carry out just in case you experience the side effects

Discontinue the drug, especially through the onset of rashes and facial/throat swelling which is indicative of an allergic reaction

In case you experience these major/small Fildena side effects, do not hesitate to contact your doctor immediately

Seek immediate medical support if the medial side effects affect your capability to function daily - Comments: 0

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